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Publication of a book chapter on the effectiveness of ChitoHeal Gel on burn wounds by Springer Nature Publisher

The results of research on the effect of ChitoHeal Gel on burn wounds was published in the book “Recent Clinical Techniques, Results, and Research in Wounds” by Springer Nature Publisher on 31 October, 2017. The results indicate that ChitoHeal is capable of restoration of the epidermis and acceleration of burn wound healing.


A Novel Chitosan-Based Gel for Burn Wounds


Soheila S. Kordestani (1) (2)

1. Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran

2. ChitoTech Inc Company, Tehran, Iran



Burns are the most common injuries caused by exposure to various sources of heat or chemicals. The epidermis consists of 95% keratinocytes which are responsible for controlling the distribution and amount of melanin pigment in melanocytes. The aim of the present study was to establish the effectiveness of a novel chitosan-based gel on the acceleration of wound healing and the original restoration of keratinocytes and melanocytes.

In this study, second-degree burn wounds were induced using seal aluminum on two different groups of rabbit, of which one group was treated using sterile gauze and the other was treated with a chitosan-based gel, named ChitoHeal®. Histopathology tests and scanning electron microscope (SEM) and transmission electron microscopy (TEM) results confirmed complete normal restoration of the epidermis, and there was no change in pigmentation and melanocyte overgrowth in the epidermis and keratinocytes.

The study exhibited that complete wound healing process with normal structured keratinocyte cells and pigmentation would take place after applying ChitoHeal® gel.


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